Nephrology Dialysis Transplantation, Vol 14, Issue 6 1472-1474, Copyright © 1999 by Oxford University Press
V Bakaev, A Efremov and I Tityaev
Background: Vitamin C is currently considered a potent
water-soluble antioxidant and it appeared reasonable to study the metabolic
changes of vitamin C in uraemia and during haemodialysis.
Methods: We measured the levels of ascorbic,
dehydroascorbic an diketogulonic acids in sera of uraemic patients before
and during haemodialysis, using the 2,4-dinitrophenylhydrazine method.
Results: The results indicate that the levels of
ascorbic and dehydroascorbic acid in uraemic sera are low in comparison
with controls, but the levels of diketogulonic acid are higher than in
healthy persons. The comparison of ratios between levels of these
substances in uraemic sera and in normal sera indicate that the oxidation
of ascorbic acid to dehydroascorbic in uraemia proceeds much slower than in
controls. We propose that uraemic patients are characterized by pronounced
deficiency of dehydroascorbic acid plasma levels, and a pronounced increase
of dehydroascorbic acid levels during haemodialysis was observed. Ratios
between plasma levels of ascorbic and dehydroascorbic acids following
haemodialysis are the same as in healthy persons.
Conclusion: Uraemic patients are characterized by
marked deficiency of the dehydroascorbic acid and this deficiency can be
partially corrected by haemodialysis. Key words:
ascorbic acid; dehydroascorbic acid; diketogulonic acid; uraemia;
haemodialysis
ORIGINAL ARTICLES
Low levels of dehydroascorbic acid in uraemic serum and the partial correction of dehydroascorbic acid deficiency by haemodialysis
Novosibirsk Medical Institute, Novosibirsk, Russia; Corresponding author at: PO Box 45, Novosibirsk 630107, Russia
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