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Nephrology Dialysis Transplantation, Vol 14, Issue 6 1430-1434, Copyright © 1999 by Oxford University Press

ORIGINAL ARTICLES

CD4dullCD8bright double-positive T-lymphocytes have a phenotype of granzyme Bpos CD8pos memory T-lymphocytes

R Rentenaar, P Wever, F van Diepen, P Schellekens, P Wertheim and I ten Berge
Renal Transplant Unit, Department of Internal Medicine, Clinical and Laboratory Immunology Unit, Department of Clinical Immunology and Rheumatology, Department of Internal Medicine and Department of Clinical Virology, Academic Medical Centre, University of Amsterdam, The Netherlands; Corresponding author at: Academic Medical Centre, Renal Transplant Unit, F4-215, PO Box 22700, 1100 DE Amsterdam, The Netherlands

Background: T-lymphocytes that co-express CD4 and CD8 antigens may be found in small percentages in the peripheral blood of healthy individuals, and have a CD4brightCD8dull phenotype. CD4dullCD8bright T-lymphocytes have been found only in temporal association with some viral infections. Methods: Four-colour flow cytometric analysis of peripheral blood mononuclear cells from a renal transplant recipient with cytomegalovirus infection performed. Results: A small but clearly distinguishable subpopulation of CD4dullCD8bright doble-positive T-lymphocytes was detected, that exhibited phenotypic characteristics of cytotoxic T-lymphocytes and were granzyme B positive. Furthermore, no naive cells appeared to be present within this subpopulation. Conclusions: CD4dullCD8bright double-positive T-lymphocytes; CMV infection; renal transplantation; memory; effector; granzyme B
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