Nephrology Dialysis Transplantation, Vol 14, Issue 5 1129-1132, Copyright © 1999 by Oxford University Press
J Bar, B Kaplan, C Wittenberg, A Erman, G Boner, Z Ben-Rafael and M Hod
Background. Microalbuminuria is an important risk
factor for underlying vascular disease. Its detection after pregnancy
complicated by pre-eclampsia may have predictive value for the later
development of chronic hypertension or renal disease. Method.
The study group consisted of 48 women in whom pregnancy had been
complicated by pre-eclampsia. Urinary albumin excretion rate, blood
pressure, and renal function parameters were assessed 2-4 months and 3-5
years after the pregnancy. Results were compared with those in 44 women
after normal pregnancy. Results. Mean urinary albumin
excretion rate was significantly higher in the study group than in the
controls both at 2-4 months after delivery (27.0±33
vs 6.1±3.3 mg/24 h) and at 3-5 years after
delivery (23.5±26.8 vs 6.7±2.8
mg/24 h) (P=0.001). The rate of occurrence of
microalbuminuria was not significantly different between the early (58%)
and late (42%) time-points within the study group or between the
nulliparous and the multiparous women. Conclusions. A
history of pregnancy complicated by pre-eclampsia is associated with a high
occurrence of microalbuminuria. Whether the presence of microalbuminuria
reflects a possible underlying vascular disease in affected patients needs
to be further investigated in large-scale studies. Keywords:
microalbuminuria; pre-eclampsia; post-delivery
ORIGINAL ARTICLES
Microalbuminuria after pregnancy complicated by pre-eclampsia
Department of Obstetrics and Gynecology, and Institute of Hypertension and Nephrology, Rabin Medical Centre, Beilinson Campus, Petah Tiqva 49 100, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; Corresponding author
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