Nephrology Dialysis Transplantation, Vol 14, Issue 3 655-658, Copyright © 1999 by Oxford University Press
G Biesenbach, A Debska-Slizien and J Zazgornik
Background. Type 2 diabetic patients with end-stage
renal disease are often overweight (BMI>24) at the start of dialysis
therapy. However, there are very few reports in the literature concerning
the nutritional status of these patients after prolonged haemodialysis
treatment. Therefore, we compared nutritional parameters in type 2 diabetic
patients and age-matched non-diabetic patients after at least 18 months of
renal replacement therapy with haemodialysis. Methods.
In a cross-sectional study, we measured BMI, serum albumin,
total protein, serum cholesterol and interdialytic weight gain (IWG), and
performed a subjective global assessment (SGA) in 14 patients with type 2
diabetes and 16 non-diabetic patients (aged ⩾50 years,
haemodialysis therapy ⩾18 months). Protein intake was estimated
using the protein catabolic rate (PCR) and Kt/V was
calculated to compare the dose of dialysis. Results.
BMI was significantly higher in patients with type 2 diabetes
(30±7 vs 24±3,
P<0.01). In contrast, the concentration of
serum albumin was significantly lower (3180±499 mg/dl
vs 3576±431 mg/dl,
P<0.05), but six of the diabetic patients had
signs of chronic inflammation. All other nutritional parameters did not
differ between the two groups. In addition, there were no significant
differences in the intake of protein (PCR 0.93±0.19
vs 0.92±0.22) and the dose of dialysis
(Kt/V 1.13±0.19 vs
1.2±0.2). Conclusion. After ⩾18
months of haemodialysis therapy, the majority of type 2 diabetic patients
(9/14) were still overweight (BMI>24). The nutritional status of
diabetic patients was similar to that of age-matched non-diabetic patients
on prolonged haemodialysis, but serum albumin levels were significantly
lower in diabetics. The lower albumin levels in the diabetic patients may
be explained by a state of subclinical chronic inflammation.
Keywords: dietary protein intake; haemodialysis;
nutritional; type 2 diabetes
ORIGINAL ARTICLES
Nutritional status in type 2 diabetic patients requiring haemodialysis
Second Department of Medicine, General Hospital Linz, Krankenhausstrasse 9, A-4020 Linz, Austria; Department of Nephrology, Gdansk Medical University, Gdansk, Poland; Corresponding author
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