Nephrology Dialysis Transplantation, Vol 14, Issue 3 648-654, Copyright © 1999 by Oxford University Press
S Aakhus, K Dahl and T Wideroe
Background. Cardiovascular disease is now the major
cause of death in renal transplant patients. This study aimed to assess the
prevalence of cardiovascular disease in stable renal transplant patients as
compared with the general background population, and to assess risk factors
for cardiovascular disease in this patient group. Methods.
A cross-sectional multicentre study comprising 406 stable renal
transplant patients (age 47±16 years, 60% males, 71% taking
cyclosporin A) were assessed clinically and biochemically 48 months
(median) after transplantation and compared with the general population.
Multivariate analysis was used to assess the relation between
cardiovascular disease and risk factors. Results.
Hypertension was present in 55% of males and 34% of females
(P<0.001), in 51% with cyclosporin A and in 33%
without (P<0.001). Ischaemic heart disease
(i.e. angina pectoris and/or previous myocardial infarction) was present in
14% (males: 18%, females; 10, P<0.05) and in
24% of diabetics vs 12% of non-diabetics
(P<0.01). Cerebro- and peripheral vascular
disease was found in 3% and 4%, respectively. Odds ratio for angina
pectoris (patients vs general population) was: in age
group 40-49 years (males/females), 12/16; 50-59 years, 6/4; 60-69 years,
3/4. Ischaemic heart disease was, besides age and gender, independently
associated with total cholesterol (P<0.01), and
peripheral vascular disease to systolic blood pressure
(P<0.01). Conclusions.
Cardiovascular disease is highly prevalent in renal transplant
patients, and is independently associated with age, gender, total
cholesterol and systolic blood pressure. Keywords:
cardiovascular disease; cross-sectional study; cyclosporin A;
ischaemic heart disease; renal transplant patients; risk factors
ORIGINAL ARTICLES
Cardiovascular morbidity and risk factors in renal transplant patients
Department of Medicine, Sections of Cardiology and Nephrology, University Hospital of Trondheim, Trondheim, Norway; Corresponding author address: Medical Department B, Section of Cardiology, The National Hospital - Rikshospitalet, 0027 Oslo, Norway
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