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Nephrology Dialysis Transplantation, Vol 14, Issue 1 113-117, Copyright © 1999 by Oxford University Press

ORIGINAL ARTICLES

Influences of Helicobacter pylori on serum pepsinogen concentrations in dialysis patients

H Tamura, H Tokushima, M Murakawa, O Matsumura, S Itoyama, T Mitarai and K Isoda
Fourth Department of Internal Medicine, Department of Pathology, Saitama Medical Centre, Saitama Medical School, 1981 Kamoda, Kawagoe, Saitama 350-8550, Japan; Corresponding author

Background: Patients with impaired renal function have been known to have elevated concentrations of serum pepsinogens, which are raised by Helicobacter pylori infection of the stomach. The present study was performed to examine the effect of H. pylori infection on serum pepsinogen concentrations in dialysis patients. Methods: Forty nine patients on dialysis and 48 subjects with no known kidney disease were examined for upper gastroduodenal endoscopy, H. pylori infection and serum concentrations of pepsinogen I and II. The status of H. pylori infection was evaluated from results of a urease test, histology and culture of biopsy specimens of the gastric mucosa. Serum pepsinogen levels were measured by radioimmunoassay. Results: Serum concentrations of pepsinogen I and II were elevated in the dialysis patients in comparison with those in the controls (277.4±24.2 vs 52.6±4.0 pg/ml, P<0.01 for pepsinogen I, and 30.2±2.9 vs 14.9±1.3 pg/ml, P<0.01 for pepsinogen II). In both the dialysis patients and controls, those with H. pylori infection had significantly higher concentrations of serum pepsinogen I and II and a lower ratio of pepsinogen I to pepsinogen II than those without infection. Among the controls, 15 of 25 subjects with atrophic gastritis had a pepsinogen I/pepsinogen II ratio ⩽3.0, while only two out of 17 patients on dialysis fell into this range. Conclusions: We conclude that H. pylori status should be taken into account when serum pepsinogen concentrations are evaluated in dialysis patients. Key words: dialysis; end-stage renal disease; gastritis; Helicobacter pylori; pepsinogen
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