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Nephrology Dialysis Transplantation, Vol 13, Issue 90007 6-11, Copyright © 1998 by Oxford University Press

ORIGINAL ARTICLES

Cardiovascular abnormalities in ageing and in uraemia - only analogy or shared pathomechanisms?

K Amann and E Ritz
Departments of Pathology and Internal Medicine, Ruperto Carola University of Heidelberg, Bergheimer Strasse 56a, D-69115 Heidelberg, Germany; Corresponding author

The analogies between the effects of ageing and of uraemia on the function and the structure of central elastic arteries and of the heart are striking. Qualitatively similar changes are seen in pulse contour, pulse wave velocity, and impedance and also similar structural abnormalities with wall thickening, diminished elastin, and increased collagen content. The altered 'Windkessel' function of central arteries in age and uraemia is one factor contributing to left ventricular hypertrophy.
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