Skip Navigation

This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Grosso, S.
Right arrow Articles by Massari, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Grosso, S.
Right arrow Articles by Massari, P.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nephrology Dialysis Transplantation, Vol 13, Issue 90003 98-102, Copyright © 1998 by Oxford University Press

ORIGINAL ARTICLES

Time course and functional correlates of post-transplant aluminium elimination

S Grosso, W Douthat, G Garay, J de Arteaga, G Boccardo, J Martin, A Canteros, J Andia and P Massari
Renal Service, Hospital Privado Centro-Medico de Cordoba, Cordoba, Argentina; Bone and Mineral Research Unit, Instituto Reina Sofia, Hospital Central de Asturias, Oviedo, Spain; Corresponding author address: Servicio de Nefrologia, Hospital Privado-Centro Medico de Cordoba, Naciones Unidas 346, (5016) Cordoba, Argentina

Urinary excretion of aluminium after a successful transplant can reverse pre-transplant aluminium intoxication. We have evaluated the time course of urinary aluminium excretion and its correlation with several parameters of renal function and mineral metabolism in 49 patients (33 men and 16 women) with a wide range of pre-transplant serum aluminium concentrations, performing sequential determinations at pre-transplant time and at 7, 30, 60, and 90 post-transplant days.Mean serum aluminium at pre-transplant was 54.5±46.8 &mgr;g/l decreasing progressively to 28.7±24.4 &mgr;g/l at 90 days (P<0.0002), paralleling the decrease in serum creatinine. Urinary aluminium decreased from 63.0±77.9 to 52.4±55.9 &mgr;g/l at 90 days (P<0.0001). The maximum urinary aluminium/creatinine was 1.8±2.7 at 7 days and was associated with the greatest fractional excretion of sodium (4.7±5.1%), and the lowest tubular reabsorption of phosphate (55.7±25.1%).The fractional excretion of aluminium was also greatest at day 7 (1.1±0.9%) when serum creatinine was still elevated (3.6±2.3 mg/dl). At each period of time after transplantation fractional excretion of aluminium was similar in all patients despite disparate serum aluminium concentrations. Fractional excretion of aluminium was highest in those patients who developed post-Tx acute tubular necrosis (0.7±0.5 vs 1.5±1.0%, P=0.008). We found a direct positive correlation (r=0.43; P<0.002) between urinary aluminium and urinary phosphate. Basal levels and sequential changes in serum PTH, calcium, and phosphate did not correlated with fractional excretion of aluminium.These findings suggest: (i) urinary aluminium remains elevated during prolonged periods after transplant and is probably a marker of pre-transplant tissue aluminium accumulation; (ii) post-transplant fractional excretion of aluminium seems to correlated positively with other evidences of renal tubular dysfunction. Early post-transplant tubular malfunction could significantly enhance urinary aluminium elimination.Keywords: aluminium; renal transplant
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.