Nephrology Dialysis Transplantation, Vol 13, Issue 90003 94-97, Copyright © 1998 by Oxford University Press
A Torres, A Rodriguez, M Concepcion, S Garcia, M Rufino, B Martin, L Perez, M Machado, E de Bonis, M Losada, D Hernandez and V Lorenzo
Lack of resolution of hyperparathyroidism after long-term renal
transplantation is common. The relative roles of the graft function
attained and the degree of pre-transplant hyperparathyroidism have not been
established. Intact parathyroid hormone (iPTH) and several clinical
parameters were studied before and 68.6±26.8 months (range:
30-124) after renal transplantation in 62 patients (20 females/42 males)
with good renal function (creatinine <2 mg/dl). iPTH decreased from
214±220 pre-transplantation to 116±70 pg/ml
post-transplantation (P<0.01). However, only
22.6% of patients had PTH concentrations in the normal range, and values
greater than twice the upper normal limit were not uncommon (27.4%). Of the
many variables analysed, creatinine (r=0.43;
P=0.01) and pre-transplant PTH
(r=0.31; P=0.02) significantly
correlated with post-transplant PTH. After selecting patients with serum
creatinine <1.5 mg/dl (n=46), pre-transplant
PTH emerged as the more important predictor of post-transplant PTH
(r=0.58; P<0.0001). After
controlling for creatinine, the partial correlation was
r=0.53, P<0.0001. We
concluded that spontaneous resolution of hyperparathyroidism after renal
transplantation is uncommon. In addition, the magnitude of pre-transplant
hyperparathyroidism and the renal function determine the long-term
post-transplant parathyroid function.Keywords: bone;
parathyroid hormone; persistent hyperparathyroidism; renal transplantation
ORIGINAL ARTICLES
Parathyroid function in long-term renal transplant patients: importance of pre-transplant PTH concentrations
Servicio de Nefrologia, Hospital Universitario de Canarias, Universidad de La Laguna, Ofra s/n, 38020 La Laguna, Tenerife, Spain; Corresponding author
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  P. Falck, N. T. Vethe, A. Asberg, K. Midtvedt, S. Bergan, J. L. E. Reubsaet, and H. Holdaas Cinacalcet's effect on the pharmacokinetics of tacrolimus, cyclosporine and mycophenolate in renal transplant recipients Nephrol. Dial. Transplant., March 1, 2008; 23(3): 1048 - 1053. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Chonchol and R. P. Wuthrich Potential Future Uses of Calcimimetics in Patients with Chronic Kidney Disease NDT Plus, January 1, 2008; 1(suppl_1): i36 - i41. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Evenepoel, K. Claes, D. R. Kuypers, F. Debruyne, and Y. Vanrenterghem Parathyroidectomy after successful kidney transplantation: a single centre study Nephrol. Dial. Transplant., June 1, 2007; 22(6): 1730 - 1737. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. C. Boudville and A. B. Hodsman Renal function and 25-hydroxyvitamin D concentrations predict parathyroid hormone levels in renal transplant patients Nephrol. Dial. Transplant., September 1, 2006; 21(9): 2621 - 2624. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Torres, V. Lorenzo, and E. Salido Calcium Metabolism and Skeletal Problems after Transplantation J. Am. Soc. Nephrol., February 1, 2002; 13(2): 551 - 558. [Full Text] [PDF]
|
|
|
|
 |
|
 S. J. Marx Hyperparathyroid and Hypoparathyroid Disorders N. Engl. J. Med., December 21, 2000; 343(25): 1863 - 1875. [Full Text] [PDF]
|
|