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Nephrology Dialysis Transplantation, Vol 13, Issue 90003 9-11, Copyright © 1998 by Oxford University Press

ORIGINAL ARTICLES

Is there a lesser hyperparathyroidism in diabetic patients with chronic renal failure?

I Martinez, R Saracho, I Moina, J Montenegro and F Llach
Servicio Nefrologia, Hospital Galdakao, Barrio Labeaga s/n, E-48960 Vizcaya, Spain; Nephrology Division, Newark Beth Israel Medical Center, Newark, NJ, USA; Corresponding author

Diabetic patients on dialysis have lower levels of parathyroid hormone (PTH); however, there is no data regarding PTH levels with different degrees of chronic renal failure (CRF). We compared 58 diabetic patients with different degrees of CRF with 268 non-diabetic patients with CRF (serum creatinine > 1.2 mg/dl). In both groups, we investigated the main biochemical parameters together with plasma calcium, phosphorus, magnesium, PTH and calcitriol. Diabetic patients showed lower levels of PTH than non-diabetics (P=0.003). The differences were observed in patients with creatinine clearance <70 ml/min. We also observed differences in phosphorus, magnesium and tubular resorption of phosphate. In the group of diabetic patients, serum glucose correlated inversely with PTH. Our study suggests that poor control of diabetes (hyperglycaemia) may play a role in the pathogenesis of the hypoparathyroidism observed in patients with diabetes and CRF.Keywords: chronic renal failure; diabetes; divalent ions; hypoparathyroidism
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