Nephrology Dialysis Transplantation, Vol 13, Issue 9 2276-2280, Copyright © 1998 by Oxford University Press
F Kokot, M Adamczak and A Wiecek
Background: Leptin, is produced by adipose tissue and
is presumed to be involved in the regulation of appetite and energy
balance. The kidneys are involved in the inactivation of circulating
leptin, and elevated plasma leptin concentrations were reported in uraemic
patients. Finally, glucocorticosteroids as used in transplanted patients
stimulate leptin secretion. Methods: The present study
aimed to assess the relationship between plasma leptin concentration and
kidney graft function in the early post-transplant period. We studied 40
successfully transplanted haemodialysed uraemic patients (27 males, 13
females, mean age 34.3±1.6 years, mean body mass index
22.5±0.5 kg/m2). The circadian rhythm of
leptinaemia and insulinaemia was assessed twice: 2-4 days after kidney
transplantation and 1 day before discharge from the hospital when graft
function was good. Plasma leptin concentration was measured at 8 am, 4 pm,
and 12 pm. The control group consisted of 21 healthy subjects (13 males, 8
females, mean age 39.4±2.5 years, mean body mass index
24.1±0.7 kg/m2).
Results: Before kidney transplantation, patients had
elevated plasma leptin and insulin levels. A positive correlation was found
between BMI and leptinaemia and BMI and insulinaemia respectively. An
inverse relationship was found between leptinaemia and age. Successful
kidney transplantation was followed by a significant decline of leptinaemia
i.e. from 21.5±0.1 vs 7.1±1.3
ng/ml. Kidney transplantation did not influence the circadian rhythm of
leptinaemia. Conclusion: Leptinaemia was not related
to the excretory graft function or immunosuppression. In addition to renal
excretory function, other factors must be involved in the post-transplant
decline of leptinaemia. Key words: kidney
transplantation; leptin; insulin
ORIGINAL ARTICLES
Plasma leptin concentration in kidney transplant patients during early post-transplant period
Department of Nephrology, Endocrinology and Metabolic Diseases, Silesian University School of Medicine, Francuska 20/24 Str., 40-027 Katowice, Poland; Corresponding author
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