Nephrology Dialysis Transplantation, Vol 13, Issue 9 2234-2240, Copyright © 1998 by Oxford University Press
M Zeier, R Schonherr, K Amann and E Ritz
Background: Renal functional prognosis is consistently
more adverse in male individuals with renal disease. Male animals develop
more marked proteinuria and glomerulosclerosis in several models of renal
damage. Renal and glomerular growth are important permissive factors for
progression of renal failure. Purpose of the study: To
investigate the influence of testosterone on renal and glomerular growth.
Design: Renal compensatory growth after uninephrectomy
(UNX) was chosen as a model of renal growth. The effect of testosterone was
assessed in control male, in orchidectomized (OX) male, and in
ovariectomized (OV) female SD rats. Observation time was 10 months.
Measurements. Albuminuria by nephelometry; glomerular
diameter, glomerular tuft area, renal zonal analysis by quantitative
stereology. Testosterone and dihydroxytestosterone by gas chromatography
and RIA. Results: In sham-operated male rats,
testosterone administration did not change the (left) kidney:body-weight
ratio after uninephrectomy. In contrast, in OX male rats, testosterone
administration caused a significant increase in kidney:body weight ratio
and in albuminuria. In these animals, glomerular diameter and outer stripe
width were significantly lower in OX rats than in sham-operated controls.
Glomerular volume and outer stripe width in OX animals were significantly
higher after uninephrectomy (UNX) and were further increased in OX-UNX
animals by administration of testosterone. Similar effects on glomerular
diameter, cortical width (single) kidney:body-weight ratio were seen when
OV female rats were treated with testosterone.
Conclusion: After gonadal ablation, administration of
testosterone amplifies compensatory glomerular and tubular growth in
uninephrectomized male and female rats, i.e. testosterone is a permissive
factor. Stimulation of glomerular growth may favour development of
glomerulosclerosis. Key words: testosterone; gender;
glomerular volume; glomerulosclerosis; renal growth
ORIGINAL ARTICLES
Effects on testosterone on glomerular growth after uninephrectomy
Department of Internal Medicine, University of Heidelberg, Berheimer Strasse 58, D-691 15 Heidelberg, Germany; Department of Pathology, Ruperto Carola University, Heidelberg, Germany; Corresponding author
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