Skip Navigation

This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (9)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Dotsch, J.
Right arrow Articles by Rascher, W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dotsch, J.
Right arrow Articles by Rascher, W.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nephrology Dialysis Transplantation, Vol 13, Issue 7 1686-1689, Copyright © 1998 by Oxford University Press

ORIGINAL ARTICLES

Increased urinary adrenomedullin excretion in children with urinary-tract infection

J Dotsch, J Hanze, V Knufer, J Steiss, K Dittrich, A Seidel and W Rascher
Departments of Pediatrics and Pathology, Justus-Liebig-Universitat, Giessen, Germany; Corresponding author at: Department of Pediatrics, Loschgestrasse 15, D-91054 Erlanden, Germany

Background: Adrenomedullin (AM), a smooth-muscle relaxant peptide, is stimulated by cytokines and bacterial endotoxins. We hypothesized that urinary-tract infections may be associated with elevated urinary AM excretion. Methods: AM in urine was quantified in eleven children with urinary-tract infection and 11 age- and sex-matched controls by radioimmunoassay. RT-PCR was used to demonstrate local AM mRNA expression in the urinary tract. Results: In healthy controls but not in diseased children there was a significant correlation between AM and creatinine in urine (r-0.91, P<0.001). AM levels in children with urinary tract infection were significantly higher than in controls (0.6±0.41 vs 0.15±0.14 ng/&mgr;mol creatinine; P<0.001; (means±SD)). There was a significant correlation between white cell count and AM in urine (r-0.78, P<0.001). AM mRNA was expressed in renal tissue, renal pelvis, ureter, bladder, and urethra. Conclusion: The smooth-muscle relaxant peptide adrenomedullin that is synthesized in tissue of the human urinary tract is elevated in urine of patients with urinary-tract infections. A possible consequence might be the interference with the ureteral anti-reflux mechanisms. Key words: adrenomedullin, inflammation, urinary tract infection
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Endocr. Rev.Home page
J. P. Hinson, S. Kapas, and D. M. Smith
Adrenomedullin, a Multifunctional Regulatory Peptide
Endocr. Rev., April 1, 2000; 21(2): 138 - 167.
[Abstract] [Full Text]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.