Nephrology Dialysis Transplantation, Vol 13, Issue 4 900-903, Copyright © 1998 by Oxford University Press
R Oberbauer, G Schreiner and T Meyer
Background: Many effects of adenosine on renal
function have been identified. The development of adenosine receptor
blockers has made it possible to identify which of these effects are
exerted by endogenous adenosine. At least four adenosine receptor subtypes,
denoted A1, A2a, A2b, and A3 are currently known. In the present study the
selective A1 receptor blocker 1,3-dipropyl-8[2-(5,6-epoxy) norbanyl]
xanthine (CVT-117) was used to assess the effect of A1 activation by
endogenous adenosine on renal function in rats.
Methods: Clearance studies were performed before and
after administration of 0.1 mg/kg and 0.8 mg/kg of CVT-117 in separate
groups of rats and before and after administration of vehicle in
time-control rats. Measurement of heart rate before and after
administration of exogenous adenosine confirmed effective A1 receptor
blockade. Results: At both the lower and higher doses,
A1 receptor blockade with CVT-117 increased fractional sodium excretion and
urine flow rate without altering GFR. The increase in sodium excretion
following A1 blockade was not accompanied by increases in the excretion of
phosphate or potassium. Conclusion: These results show
that endogenous adenosine promotes sodium retention by activation of A1
receptors. Key words: adenosine; diuretic; glomerular
filtration rate; receptor; sodium
ORIGINAL ARTICLES
Natriuretic effect of adenosine A1-receptor blockade in rats
Departments of Medicine, University of Vienna,, Vienna, Austria; VA Palo Alto HCS and Stanford University, and CV Therapeutics, Palo Alto, CA, USA; Corresponding author at: Division of Nephrology, Department of Internal Medicine, University of Vienna, Wahringer Gurtel 18-20, A-1090 Vienna, Austria
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