Nephrology Dialysis Transplantation, Vol 13, Issue 4 867-874, Copyright © 1998 by Oxford University Press
S Waldegger, S Steuer, T Risler, A Heidland, G Capasso, S Massry and F Lang
A wide variety of factors challenge constancy of cell volume. Alterations
of cell volume activate diverse cell volume regulatory mechanisms including
ion transport, osmolyte accumulation, metabolism and expression of
appropriate genes. A wealth of cellular signalling pathways link cell
volume to the respective regulatory mechanisms. Cell volume emerges as a
pathophysiologically important parameter in several diseases including
diabetes mellitus, uraemia, hepatic insufficiency and hypercatabolic
states. The role of altered cell volume in disease is a challenge which
requires more experimental research and clinical investigation.
ORIGINAL ARTICLES
Molecular basis of renal disease. Mechanisms and clinical significance of cell volume regulation
Departments of Physiology and Internal Medicine, University of Tubingen, Gmelinstrasse 5, D-72076 Tubingen, Germany; Kuratorium fur Nephrologie, Wurzburg, Germany; Department of Nephrology, Second University of Napoli, Italy; Division of Nephrology, University of Southern California, Los Angeles, CA, USA; Corresponding author
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