Nephrology Dialysis Transplantation, Vol 13, Issue 11 2861-2866, Copyright © 1998 by Oxford University Press
Y Matsumoto, T Shinzato, I Takai, A Nishimoto, S Nakai, T Sakai, I Amano and K Maeda
Many patients with end-stage renal disease have altered host defenses
against infectious agents. We have demonstrated that T cells, which play an
important role in the immunological response, may undergo apoptosis by the
Fas system in uraemia. To elucidate whether &ggr;&dgr; T cells,
which function as a first defense against intracellular pathogens, are
altered in number or characteristics in dialysis patients surface
expressions of TCR, LFA-1 and Fas antigen on peripheral T cells were
examined by immunofluorescence analysis. We demonstrated the proportions of
peripheral &ggr;&dgr; T cells are altered significantly in
haemodialysis (HD) patients. Interestingly, there were marked differences
in the levels of expression of LFA-1 and Fas antigen between the two types
of T cells. Moreover both the expression of LFA-1 and that of Fas antigen
were enhanced significantly in HD patients compared with normal controls.
These results suggest that circulating &ggr;&dgr; T cells may be
susceptible to activation-induced cell death in comparison with
&agr;{beta} T cells in uraemic environments. Key
words: end-stage renal disease; FAS; &ggr;&dgr; T cells;
LFA-1
ORIGINAL ARTICLES
Peripheral deletion of &ggr;&dgr; T cells in haemodialysis patients
Department of Internal Medicine, Nagoya University Daiko Medical Center, 1-1-20 Diko-minami, Higashi-ku, Nagoya 461, Japan; 1st Department of Internal Medicine, Nagoya University School of Medicine and Department of Hemodialysis, Shakaihoken-Chukyo Hospital, Nagoya, Japan; Corresponding author
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