Skip Navigation

This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (20)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Kedziora-Kornatowska, K.
Right arrow Articles by Pawlak, W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kedziora-Kornatowska, K.
Right arrow Articles by Pawlak, W.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nephrology Dialysis Transplantation, Vol 13, Issue 11 2829-2832, Copyright © 1998 by Oxford University Press

ORIGINAL ARTICLES

Lipid peroxidation and activities of antioxidant enzymes in erythrocytes of patients with non-insulin dependent diabetes with or without diabetic nephropathy

K Kedziora-Kornatowska, M Luciak, J Blaszczyk and W Pawlak
Department of Internal Diseases and Department of Physiology, Military Medical University, Plac J Hallera No 1, 90-647 Lodz, Poland; Corresponding author

Background: Diabetes is known to involve oxidative stress. However, data on oxidative stress in diabetic nephropathy is scant. The aim of this study was to examine lipid peroxidation and activities of key antioxidant enzymes in non-insulin dependent diabetes (NIDDM) without nephropathy and in those with diabetic nephropathy. Methods: Twenty-one NIDDM outpatients with obvious diabetic nephropathy (persistent proteinuria, over 0.5 g/day and albumin excretion over 200 &mgr;g/min), 14 NIDDM outpatients with a long diabetic history but without hypertension and with normal urinary albumin excretion rate (<20 &mgr;g/min) and 19 healthy persons were studied. Malondialdehyde (MDA) content of erythrocytes was quantified by HPLC according to Young et al. In erythrocytes superoxide dismutase (SOD) activity was determined by adrenaline method of Misra and Fridovich and catalase was estimated according to Beers and Sizer. Results: MDA content was significantly elevated in erythrocytes of NIDDM patients without nephropathy vs the control group and even higher in erythrocytes of NIDDM patients with diabetic nephropathy. SOD and catalase activities were lower in erythrocytes of NIDDM patients without nephropathy than in the control group and lowest in erythrocytes of NIDDM patients with nephropathy. Conclusions: These results confirm oxidative stress in erythrocytes of NIDDM patients with nephropathy. The intensity of oxidative stress appeared to be greater than in NIDDM patients without nephropathy. Key words: catalase; diabetic nephropathy; lipid peroxidation; oxidative stress; superoxide dismutase
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Am. Soc. Nephrol.Home page
H. Fujita, H. Fujishima, S. Chida, K. Takahashi, Z. Qi, Y. Kanetsuna, M. D. Breyer, R. C. Harris, Y. Yamada, and T. Takahashi
Reduction of Renal Superoxide Dismutase in Progressive Diabetic Nephropathy
J. Am. Soc. Nephrol., June 1, 2009; 20(6): 1303 - 1313.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
C. S. Shin, B. S. Moon, K. S. Park, S. Y. Kim, S. J. Park, M. H. Chung, and H. K. Lee
Serum 8-Hydroxy-Guanine Levels Are Increased in Diabetic Patients
Diabetes Care, April 1, 2001; 24(4): 733 - 737.
[Abstract] [Full Text]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.