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Nephrology Dialysis Transplantation, Vol 13, Issue 10 2563-2565, Copyright © 1998 by Oxford University Press

ORIGINAL ARTICLES

Severe experimental uraemia does not decrease the population of rat pituitary somatotrophs

J Rodriguez, E Carbajo-Perez, F Santos, S Carbajo, N Ferna, P Fernandez, M Fernandez and E Garcia
Departments of Paediatrics and Morphology and Cell Biology, Faculty of Medicine, University of Oviedo, C/Julian Claveria 6, E-33006, Oviedo, Spain; Department of Anatomy and Histology, Universidad de Salamanca, Salamanca, Spain; Corresponding author

Background. Growth hormone (GH) secretion by the anterior pituitary has been shown to be depressed in severely uraemic rats. Changes in the population of pituitary somatotrophs might be partially responsible for this disease. Methods. To analyse the population of pituitary somatotrophs in severe uraemia, immunocytochemical detection and quantification of GH-producing cells were carried out on paraffin sections from young rats either 5/6 nephrectomized, sham-operated fed ad libitum or sham-operated pair-fed with the nephrectomized animals. Results. Nephrectomized rats were severely uraemic and growth retarded. The overall cell density (total pituitary cells/mm2) was higher in 5/6 nephrectomized animals in comparison with the two sham-operated groups. Thus, although the percentage of GH cells was slightly lower in nephrectomized than in control rats, no difference in either the density (cells/mm2) or the cross-sectional area of GH cells was found among groups. Conclusions. These results suggest that severe experimental uraemia interferes with the maturation process of the pituitary gland and support the contention that differences in either the number or the size of pituitary somatotrophs cannot explain the reduced GH secretion previously reported in severely uraemic rats. Keywords: chronic renal failure; growth hormone; growth; immunohistochemistry; pituitary somatotrophs; rat
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