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Nephrology Dialysis Transplantation, Vol 13, Issue 1 93-98, Copyright © 1998 by Oxford University Press

ORIGINAL ARTICLES

Clinical impact of GB-C virus in haemodialysis patients

B Kallinowski, R Ahmadi, S Seipp, J Bommer and W Stremmel
Department of Internal Medicine IV, Department of Nephrology, University of Heidelberg, Berghemer Str. 58, D-69115 Heidelberg, Germany; Corresponding author

Background: Haemodialysis patients run a high risk of acquiring viral hepatitis B (HBV) or C (HCV) infection. Recently a new parenterally transmittable RNA virus, designated GBV-C, was isolated. Methods: We therefore screened 277 patients on maintenance dialysis and 358 blood donors as a control group for GBV-C by nested PCR and correlated the data with AST, ALT, duration of dialysis, transfusion, renal transplants and coinfections with HBV and HCV. Results: The prevalence of GBV-C among haemodialysis patients was 7.9%, and 3.6% among blood donors. Neither duration of dialysis nor number of blood transfusions were associated with GBV-C infection, whereas GBV-C positive patients were significantly more often transplanted than GBV-C-negative individuals. Transaminases of GBV-C-positive individuals remained within normal limits in all haemodialysis patients and normal in all infected blood donors. Coinfections of GBV-C with HBV and HCV were only present in 0.7% and 1% respectively. Conclusions: We conclude that GBV-C virus infection is frequent among haemodialysis patients. Transaminases cannot serve as surrogate markers, and parenteral as well as community-acquired infection seems to be possible. Key words: GBV-C; haemodialysis; viral hepatitis
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