Nephrology Dialysis Transplantation, Vol 12, Issue 9 1916-1920, Copyright © 1997 by Oxford University Press
P Lim, C Liu, C Hong and Y Wei
Background. Several studies have demonstrated that
atherosclerotic complications are the major cause of morbidity and
mortality in end-stage renal disease (ESRD) patients on dialysis. The
allele &egr;4 of apolipoprotein E (ApoE) gene has been associated with
an increased risk for ischaemic cerebrovascular disease (ICVD) in general
populations in recent preliminary cross-sectional studies.
Methods. The aim of our study was to prospectively
investigate the risk of ischaemic cerebrovascular disease wit respect to
the presence of Apo &egr;4 allele in 157 Chinese uraemic patients.
Results. During the 2 year follow-up, the incidence of
stroke was 6.4% and the cumulative occurrence of ischaemic cerebrovascular
disease was 9.6%. Further analysis showed that the cumulative occurrence of
ischaemic cerebrovascular disease was 5.6% in subjects with no ApoE
&egr;4 allele and 36.8% in those with one or two ApoE &agr;4
alleles. Univariate analysis showed that the prevalence of ischaemic
cerebrovascular disease was significantly higher in the subjects with ApoE
&egr;4 allele. The mean ApoA1 plasma concentrations was significantly
lower in those with ApoE &egr;4 allele. A stepwise regression analysis
showed that the presence of stroke was significantly related to the ApoE
&egr;4 genotype (P<0.001). Conclusions. The
ApoE &egr;4 allele can be regarded as an important risk factor for
ischaemic cerebrovascular disease in uraemic patients.
ORIGINAL ARTICLES
Prevalence of apolipoprotein E genotypes in ischaemic cerebrovascular disease in end-stage renal disease patients
Department of Nephrology, Department of Neurology, Kuang Tien General Hospital, 117 Sha Tien Road, Shalu, Taichung, Taiwan; Department of Neurology, Taichung Municipal Aging Care Hospital, Taichung, Taiwan 400; Institute of Clinical Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan 112; Department of Psychiatry, Veterans General Hospital-Atipei, Taipei, Taiwan 112; Department of Biochemistry and Center for Cellular and Molecular Biology, National Yang-Ming University, Tapei, Taiwan 112; Corresponding author
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