Nephrology Dialysis Transplantation, Vol 12, Issue 7 1376-1380, Copyright © 1997 by Oxford University Press
LJ Petersen, JR Petersen, U Talleruphuus, SD Ladefoged, J Mehlsen and HA Jensen
BACKGROUND: The pulsatility index (PI) and the resistive index (RI) are
used as pulsed-wave Doppler measurements of downstream renal artery
resistance. PI and RI have been found to correlate with renal vascular
resistance, filtration fraction and effective renal plasma flow in chronic
renal failure. The aim of the present study was to evaluate the potential
relationship between these indices and the rate of decline in renal
function, as reflected by changes in different parameters of renal function
in patients with chronic renal failure. METHODS: Twenty- one patients (8
females; 13 males, mean age 58 years (36-75)) with chronic renal failure
were enrolled in the study. Doppler examinations were performed in the
segmental arteries by an Acuson 128XP. The PI and the RI was calculated
from the blood flow velocities. Parameters of renal function were measured
every 3 1/2 months, and all patients were followed for 18-21 months.
Progression of renal dysfunction was estimated by linear regression of
parameters of renal function versus time. RESULTS: In a multiple regression
analysis both PI and RI correlated significantly to the rate of decline in
reciprocal serum creatinine (PI: r = -0.48, P = 0.03; RI: r = -0.52, P =
0.02). Furthermore, when separating the patients in two groups by the
median RI value, there was a significant difference between the groups in
rate of decline in reciprocal serum creatinine (P = 0.02). For PI this
distinction was also present (P = 0.04). CONCLUSION: PI and RI correlated
to the severity of the renal disease, as reflected by the rate of decline
in reciprocal serum creatinine during antihypertensive treatment. The
median RI or PI value could separate the patients into groups one of slow
and another of fast progression.
ORIGINAL ARTICLES
The pulsatility index and the resistive index in renal arteries. Associations with long-term progression in chronic renal failure
Department of Nephrology, Hvidovre Hospital, Denmark.
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