Nephrology Dialysis Transplantation, Vol 12, Issue 6 1218-1222, Copyright © 1997 by Oxford University Press
T Wang, A Qureshi, O Heimburger, J Waniewski, C Chen, J Bergstrom and B Lindholm
Background. The surface-active substance dioctyl
sodium sulphosuccinate (DSS) has been reported to increase the peritoneal
clearances of urea and creatinine. This study investigated the effects of
DSS on the fluid and solute transport characteristics of the peritoneum.
Design. A 4-h single-dwell experiment session of
peritoneal dialysis using 25 ml of 3.86% glucose dialysis solution with an
intraperitoneal volume maker was performed in 16 male Sprague-Dawley rats.
In eight rats, 0.005% (50 p.p.m.) DSS was added to the dialysis fluid. No
DSS was given to the other eight rats (control group). The transport of
fluid, glucose, potassium, sodium, urea, phosphate and urate were analysed.
Results. There was a significant increase in the
intraperitoneal volume in the DSS group (33.0±2.9 ml) was
significantly higher compared to the control group (28.8±2.1 ml.
P<0.01). This increase in the drain volume was
mainly due to a decrease in peritoneal fluid absorption rate in the DSS
group (0.040±0.013 ml/min) as compared to the control group
(0.054±0.010 ml/min, P0.05). There was no
significant difference in the diffusive permeability and sieving
coefficient for the small solutes between these two group. However, the
clearances for urea and sodium were higher in the DSS group, mainly due to
the increase in the dialysate volume. Conclusion. Our
results suggest that DSS significantly increases the net ultrafiltration of
peritoneal dialysis. This effect, which was mainly due to a decrease in the
fluid absorption rate, contributed to the increased clearances for urea and
sodium. DSS did not alter the diffusive permeability and sieving
coefficient for the small solutes. Keywords: dioctyl
sodium sulphosuccinate; lymphatic absorption; peritoneal dialysis;
ultrafiltration
ORIGINAL ARTICLES
Dioctyl sodium sulphosuccinate increases net ultrafiltration in peritoneal dialysis
Divisions of Baxter Novum and Renal Medicine, Department of Clinical Science, K-56, Huddinge University Hospital, Karolinska Institute, S-141 86 Huddinge, Sweden; Baxter Healthcare Corporation, McGaw Park, IL USA; Corresponding author
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