Nephrology Dialysis Transplantation, Vol 12, Issue 5 899-903, Copyright © 1997 by Oxford University Press
H Haller, J Park, D Dragun, A Lippoldt and F Luft
How an increase in blood pressure, in and of itself, induces hypertensive
nephrosclerosis is unclear. In an earlier study we found that leukocyte
infiltration, proximal tubular cell proliferation, matrix deposition and
interstitial fibrosis occur in the unclipped kidney of 2 K 1 C Goldblatt
hypertensive rats. In this study we tested the hypothesis that the cell
surface adhesion molecule ICAM-1 is expressed on the vascular endothelium
and tubular epithelium of unclipped kidneys at 4 weeks. As a positive
control, we examined the clipped kidney as well. We found that systolic
blood pressure was significantly elevated in renovascular hypertensive rats
compared to sham-operated controls after 4 weeks (198 ± 5 mmHg
vs 121 ± 2 mmHg, P
<0.001). Furthermore, quantitative (densitometry) measurements
showed that ICAM-1 expression on vascular endothelium and on tubular cells
was significantly increased in unclipped kidneys compared to controls
(P <0.05). The same was true for monocyte and
granulocyte infiltration (P <0.05). These same
variables were even more prominent in the clipped kidneys, compared to
unclipped and control kidneys (P < 0.05). Our
data show that ICAM-1 is expressed in unclipped kidneys exposed to
hypertension as well as in clipped kidneys exposed to ischemia. We suggest
that mechanical injury induced by increased blood pressure is responsible
for an inflammatory adhesion molecule-mediated response and concomitant
renal injury. Keywords: renovascular hypertension;
hypertension-induced nephrosclerosis; adhesion molecules; ICAM
ORIGINAL ARTICLES
Leukocyte infiltration and ICAM-1 expression in two-kidney one-clip hypertension
Franz Volhard Clinic, Wiltberg Strasse 50, 13122 Berlin, Germany
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  M. L. Graciano, A. Nishiyama, K. Jackson, D. M. Seth, R. M. Ortiz, M. C. Prieto-Carrasquero, H. Kobori, and L. G. Navar Purinergic receptors contribute to early mesangial cell transformation and renal vessel hypertrophy during angiotensin II-induced hypertension Am J Physiol Renal Physiol, January 1, 2008; 294(1): F161 - F169. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. L. Graciano, C. R. Mouton, M. E. Patterson, D. M. Seth, J. J. Mullins, and K. D. Mitchell Renal vascular and tubulointerstitial inflammation and proliferation in Cyp1a1-Ren2 transgenic rats with inducible ANG II-dependent malignant hypertension Am J Physiol Renal Physiol, June 1, 2007; 292(6): F1858 - F1866. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. M. Steinmetz, S. Sadaghiani, U. Panzer, C. Krebs, C. Meyer-Schwesinger, T. Streichert, S. Fehr, I. Hamming, H. van Goor, R. A. K. Stahl, et al. Antihypertensive therapy induces compartment-specific chemokine expression and a Th1 immune response in the clipped kidney of Goldblatt hypertensive rats Am J Physiol Renal Physiol, February 1, 2007; 292(2): F876 - F887. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. H. Kim, H. J. Ahn, Y. S. Kim, S. I. Kim, H. S. Kim, and H. J. Jeong Urinary HLA-DR and CD54 expression--indicators for inflammatory activity in decoy cell shedding patients Nephrol. Dial. Transplant., September 1, 2006; 21(9): 2601 - 2606. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Sanz-Rosa, M. P. Oubina, E. Cediel, N. de las Heras, O. Vegazo, J. Jimenez, V. Lahera, and V. Cachofeiro Effect of AT1 receptor antagonism on vascular and circulating inflammatory mediators in SHR: role of NF-{kappa}B/I{kappa}B system Am J Physiol Heart Circ Physiol, January 1, 2005; 288(1): H111 - H115. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. E. Callera, A. C. Montezano, R. M. Touyz, T. M.T. Zorn, M. H. C. Carvalho, Z. B. Fortes, D. Nigro, E. L. Schiffrin, and R. C. Tostes ETA Receptor Mediates Altered Leukocyte-Endothelial Cell Interaction and Adhesion Molecules Expression in DOCA-Salt Rats Hypertension, April 1, 2004; 43(4): 872 - 879. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. M. Tham, B. Martin-McNulty, Y.-x. Wang, D. W. Wilson, R. Vergona, M. E. Sullivan, W. Dole, and J. C. Rutledge Angiotensin II is associated with activation of NF-{kappa}B-mediated genes and downregulation of PPARs Physiol Genomics, October 2, 2002; 11(1): 21 - 30. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. LIU, J. LUTZ, B. ANTUS, Y. YAO, S. BAIK, F. ILLIES, and U. HEEMANN Recipient Age and Weight Affect Chronic Renal Allograft Rejection in Rats J. Am. Soc. Nephrol., August 1, 2001; 12(8): 1742 - 1749. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Kiarash, P. J. Pagano, M. Tayeh, N.-E. Rhaleb, and O. A. Carretero Upregulated Expression of Rat Heart Intercellular Adhesion Molecule-1 in Angiotensin II- but Not Phenylephrine- Induced Hypertension Hypertension, January 1, 2001; 37(1): 58 - 65. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Almirall, I. Mendez, R. Comet, and X. Andreu Nephrotic syndrome after renal percutaneous transluminal angioplasty Nephrol. Dial. Transplant., October 1, 2000; 15(10): 1696 - 1699. [Full Text] [PDF]
|
|
|
|
|
|
D. N. Muller, R. Dechend, E. M. A. Mervaala, J.-K. Park, F. Schmidt, A. Fiebeler, J. Theuer, V. Breu, D. Ganten, H. Haller, et al. NF-{kappa}B Inhibition Ameliorates Angiotensin II-Induced Inflammatory Damage in Rats Hypertension, January 1, 2000; 35(1): 193 - 201. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. F. HALLORAN, A. MELK, and C. BARTH Rethinking Chronic Allograft Nephropathy: The Concept of AcceleratedSenescence J. Am. Soc. Nephrol., January 1, 1999; 10(1): 167 - 181. [Full Text]
|
|
|
|
|
|
F. C. Luft, E. Mervaala, D. N. Muller, V. Gross, F. Schmidt, J. K. Park, C. Schmitz, A. Lippoldt, V. Breu, R. Dechend, et al. Hypertension-Induced End-Organ Damage : A New Transgenic Approach to an Old Problem Hypertension, January 1, 1999; 33(1): 212 - 218. [Abstract] [Full Text] [PDF]
|
|