Nephrology Dialysis Transplantation, Vol 12, Issue 4 713-717, Copyright © 1997 by Oxford University Press
M Gotoh, S Nagase, K Aoyagi, A Hirayama, K Takemura, A Ueda, C Tomida, H Kikuchi and A Koyama
BACKGROUND: Patients with end-stage renal disease are thought to be in a
highly peroxidative state, based on studies showing decreased serum
antioxidant activity and increased peroxidative products. In this study we
confirm these findings by examining lipid peroxidation in subcutaneous fat
tissue in uraemia. SUBJECTS AND METHODS: Twenty-seven subcutaneous fat
samples were taken from patients with end-stage renal disease when they
underwent intervention for arteriovenous fistula for haemodialyis or for
catheter insertion for continuous ambulatory peritoneal dialysis. The
control samples were taken from 11 patients with normal renal function and
without any history of renal disease who had surgical interventions. Lipid
peroxides were measured as thiobarbituric acid reactive substance. RESULTS:
The concentration of thiobarbituric acid reactive substances in
subcutaneous fat tissue in the patients with end-stage renal disease is
1.223 +/- 0.636 nmol/mg fat tissue (mean +/- SD) whereas the level in the
control group is 0.097 +/- 0.054 nmol/mg fat tissue. A comparison of the
two groups by Student's t test revealed a highly significant difference (P
< 0.001). CONCLUSIONS: This study supports the finding of a severe
peroxidative state in patients with end-stage renal disease.
ORIGINAL ARTICLES
Thiobarbituric acid reactive substances are increased in the subcutaneous fat tissue of patients with end-stage renal disease
Department of Internal Medicine, University of Tsukuba, Ibaraki, Japan.
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