Nephrology Dialysis Transplantation, Vol 12, Issue 4 669-679, Copyright © 1997 by Oxford University Press
M Kitamura and TS Suto
TGF-beta has been considered as the key regulator in the generation of
glomerulosclerosis. Despite abundant descriptive data, it still remains
undetermined whether sustained, local expression of TGF-beta leads to
irreversible glomerulosclerosis. There is no doubt that TGF-beta stimulates
ECM production in the glomerulus, but this molecule has several
anti-inflammatory properties as well. Towards a better understanding of the
pathogenesis of glomerulonephritis and for the development of novel and
efficient therapeutic interventions, extensive efforts should be made to
clarify the 'bright side' of TGF-beta as well as its 'dark side' in
individual experimental and human diseases, focusing especially on the
concentration and the time-point at which its anti-inflammatory properties
spill over into its prosclerotic actions.
REVIEWS
TGF-beta and glomerulonephritis: anti-inflammatory versus prosclerotic actions
Department of Medicine, University College London Medical School, UK.
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