Nephrology Dialysis Transplantation, Vol 12, Issue 12 2683-2686, Copyright © 1997 by Oxford University Press
D Ducloux, Y Saint-Hillier and J Chalopin
Purpose of study: To evaluate the effect of
angiotensin II type 1 receptor antagonist, losartan, on post-transplant
erythrocytosis. Methods: We retrospectively analyzed
the influence of losartan therapy on haemoglobin levels of renal transplant
recipients. Twenty-eight patients who received losartan therapy to control
hypertension were divided into two groups. In 10 patients, losartan therapy
was initiated after treatment with ACE inhibitors which was discontinued
due to adverse reactions (group A). Group B consisted of 18 patients
treated with losartan who had never received ACE inhibitors.
Results: There was no difference in mean haemoglobin
concentration and haematocrit between the two groups before the onset of
losartan therapy. In Group B, mean haemoglobin concentration and
haematocrit decreased from 137±20 g/l and 0.4 at the start of
losartan therapy to 120±16 g/l (P <0.0005) and 0.35 (P
<0.0005), respectively 3 months later. In Group A, neither
haemoglobin nor haematocrit differed between the onset of losartan therapy
and the end of the study. Serum creatinine increased from 158
&mgr;mol/l±78 to 172 &mgr;mol/l±80 in Group B
(P 7lt;0.005), but remained stable in Group A. Plasma protein
concentrations remained stable in each group and there was no change in
diuretic therapy during the study. Conclusion: Our
study suggests that losartan therapy decreases haemoglobin in renal
transplant recipients.
PRELIMINARY REPORTS
Effect of losartan on haemoglobin concentration in renal transplant recipients - a retrospective analysis
Department of Nephrology and Renal Transplantation, Hospital Saint Jacques, Besancon, France; Corresponding author
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