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Nephrology Dialysis Transplantation, Vol 12, Issue 12 2517-2520, Copyright © 1997 by Oxford University Press

DIALYSIS AND TRANSPLANTATION NEWS

The prevalence and treatment of end-stage renal disease in an Asian child population

N Moghal, D Milford, S Hulton and C Taylor
The Michael Winterborn Dialysis Service, Birmingham Children's Hospital NHS Trust, Ladywood Middleway, Ladywood, Birmingham B16 8ET, UK; Corresponding author

Background: There are significant differences in the incidence aetiology of end-stage renal disease (ESRD) between the Asian and white adult population in the UK. The aim of this study as to determine if similar differences occurred in the paediatric ESRD population. Methods: A retrospective study of children with ESRD presenting between 1980 and 1995 in the population served by the Birmingham Children's Hospital. Results: Asian children comprised 7.4% of the total child population (0-13 years). ESRD developed in 165 children (138 white, 27 Asian). The prevalence of ESRD for whites was 15 per 105 white child population and for Asians, 40 per 105 Asian child population. A genetic aetiology was noted in 16 (19%) whites and 12 (44%) Asians (P <0.001). Of the 147 renal transplants, 22 (15%) were to Asian recipients. The distribution of blood groups in the two populations reflected the pattern in the respective general populations as a whole. There was no significant difference in time to transplantation for the two groups (whites, mean 6 months, 95% confidence interval 6-11 months; Asians, mean 7 months, 95% CI 4-12 months). Asian patients had significantly more mismatches (⩽3 or ⩽4) compared to white patients. Conclusion: Asian children had a higher prevalence of ESRD, with genetic disease predominating. Differences in ethnicity or blood group did not influence time to transplantation in those that received a transplant although Asians had more mismatches. Key words: Asian; prevalence; genetic disease; consanguineous; HLA matching
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