Nephrology Dialysis Transplantation, Vol 12, Issue 10 2075-2080, Copyright © 1997 by Oxford University Press
T Wa, A Macnicol and M Watson
Background: Ambulatory blood pressure is more closely
correlated with various indices of hypertensive target-organ damage, and is
a better prognostic predictor of cardiovascular morbidity and mortality
than conventional methods of blood pressure measurement. Autosomal dominant
polycystic kidney disease (ADPKD) is complicated by hypertension,
progressive renal failure, and an increased risk of cardiovascular
mortality. This study investigated the 24-h ambulatory blood pressure
profile in patients with ADPKD in view of the sparsity of such data in
these patients and the possibility that abnormal diurnal blood pressure
variations may have prognostic consequences. Methods:
Ambulatory blood pressure was measured over a 24-h period by the
oscillometric method with an automatic non-invasive recorder (SpaceLabs
90207 system) in matched groups of 25 hypertensive patients with ADPKD and
25 patients with essential hypertension. Results: Both
groups showed a nocturnal decrease in blood pressure, but this was
significantly smaller in patients with ADPKD. There was no evidence of
enhanced lability of blood pressure in ADPKD.
Conclusion: The nocturnal fall in blood pressure was
attenuated in patients with ADPKD. Further studies are required to assess
the importance of this finding and its possible contribution to the
progression of renal failure or increased cardiovascular mortality in these
patients. Keywords: ambulatory blood pressure;
autosomal dominant polycystic kidney disease; hypertension
ORIGINAL ARTICLES
Ambulatory blood pressure in hypertensive patients with autosomal dominant polycystic kidney disease
Department of Medicine, The Royal Infirmary, Edinburgh, UK; Corresponding author at: Department of Medicine, The Martin Wing, The General Infirmary, Great George Street, Leeds LS1 3EX, UK
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  T. Elung-Jensen, S. Strandgaard, and A.-L. Kamper Longitudinal observations on circadian blood pressure variation in chronic kidney disease stages 3-5 Nephrol. Dial. Transplant., September 1, 2008; 23(9): 2873 - 2878. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. B. Davidson, J. K. Hix, D. G. Vidt, and D. J. Brotman Association of Impaired Diurnal Blood Pressure Variation With a Subsequent Decline in Glomerular Filtration Rate. Arch Intern Med, April 24, 2006; 166(8): 846 - 852. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. A. VALERO, A. MARTINEZ-VEA, A. BARDAJÍ, C. GUTIERREZ, C. GARCIA, C. RICHART, and J. A. OLIVER Ambulatory Blood Pressure and Left Ventricular Mass in Normotensive Patients with Autosomal Dominant Polycystic Kidney Disease J. Am. Soc. Nephrol., May 1, 1999; 10(5): 1020 - 1026. [Abstract] [Full Text]
|
|