Nephrology Dialysis Transplantation, Vol 12, Issue 1 93-96, Copyright © 1997 by Oxford University Press
S Flecher, A Brownjohn, C Dunwell and P Harnden
Background. The vitamin D receptor is expressed in
nuclei of parathyroid cells and plays an important role in the regulation
of cell growth and parathyroid hormone secretion. A number of studies have
shown reduced receptor expression in uraemic parathyroid glands but the
relationship between receptor expression and renal function has not been
identified. Methods. This study used archive
parathyroid tissue from patients with primary adenomas, dialysis patients
with diffuse hyperplasia secondary to uraemia and normal parathyroid
tissue. An immunocytochemical assay with a vitamin D receptor antibody was
used to identify parathyroid cells expressing receptor in their nuclei.
Results. In patients with a serum creatinine
⩽110 &mgr;mol/l, 81.94%±6.5 of parathyroid cells
expressed vitamin D receptor. This fell to a mean of 49.3% in two patients
with a serum creatinine between 110 and 300 &mgr;mol/l and to
40.17%±8.6 in dialysis patients.
Conclusion. Vitamin D receptor expression in
parathyroid glands is reduced in renal failure.
Keywords: chronic renal failure; immunocytochemistry;
1,25 dihydroxyvitamin D3 receptor
ORIGINAL ARTICLES
Immunocytochemical detection of a reduction in 1,25 dihydroxyvitamin D3 receptor expression in uraemic parathyroid tissue
Renal Unit and Department of Histopathology, Leeds General Infirmary, Great George Street, Leeds LS1 3EX, UK; Corresponding author
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  S. B. Brown, T. T. Brierley, N. Palanisamy, I. B. Salusky, W. Goodman, M. L. Brandi, T. B. Drüeke, E. Sarfati, P. Ureña, R. S. K. Chaganti, et al. Vitamin D Receptor as a Candidate Tumor-Suppressor Gene in Severe Hyperparathyroidism of Uremia J. Clin. Endocrinol. Metab., February 1, 2000; 85(2): 868 - 872. [Abstract] [Full Text]
|
|