Nephrology Dialysis Transplantation, Vol 12, Issue 1 71-77, Copyright © 1997 by Oxford University Press
S Ball, T Cook, B Hulme, A Palmer and D Tauber
Background. There is a high incidence of renal disease
in the ethnically Indian population in the United Kingdom, the pathological
basis for which is only partly understood. This study attempted to define
associations between renal biopsy diagnosis and race. The aim was thereby
to identify types of renal disease which may contribute to the observed
predisposition to renal failure in the Indian population served by our
center. Methods. A single-centre-based retrospective
analysis of the final diagnosis and corresponding ethnicity in 394
consecutive patients undergoing native renal biopsy for the investigation
of abnormal renal function or urinary sediment.
Results. A highly significant association between a
diagnosis of interstitial nephritis and Indian race was observed. There
were 30 cases of interstitial nephritis, of whom 17 were Indian. In 15 of
the Indian patients no aetiology could be established. The clinical
features, outcomes, and the effect of steroid therapy in the Indian
patients with idiopathic interstitial nephritis are described.
Conclusion. Idiopathic interstitial nephritis is
associated with Indian racial origin. This pathology may significantly
contribute to the high incidence of end-stage renal failure in Indian
patients resident in the United Kingdom. Keywords:
chronic renal failure; ethnicity; interstitial nephritis; renal biopsy
ORIGINAL ARTICLES
The diagnosis and racial origin of 394 patients undergoing renal biopsy: an association between Indian race and interstitial nephritis
Transplant and Renal Unit, Clarence Wing, and Department of Histopathology, St Mary's Hospital Medical School, Praed Street, London W2 1NY, UK; Corresponding author
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