Nephrology Dialysis Transplantation, Vol 12, Issue 1 184-186, Copyright © 1997 by Oxford University Press
T Mak, C Cheung, C Cheung, C Leung, C Lam and K Lai
Background. High glucose concentration in CAPD fluid
is known to interfere with creatinine measurement, which is required for
assessment of peritoneal membrane permeability and adequacy of dialysis.
Correction formulae have been proposed but they may be
method/analyser-dependent. We studied such interference in detail.
Methods. CAPD fluid was diluted to prepare six
specimens with glucose concentrations ranging from 9.1 t 154.4 mmol/l. To
each specimen, creatinine standard was added to give five different
concentrations from 50 to 800 &mgr;mol/l. The 30 specimens were assayed
for creatinine with six routine clinical chemistry analysers (Hitachi 911
and 747, Technicon RAXT and SMAC3, Bechman CX7, and Kodak Ektachem 700).
Creatinine interference was calculated by subtracting the apparent
creatinine concentration with corresponding baseline creatinine
concentration (measured at glucose=9.1 mmol/l) in the same series.
Results. At constant creatinine concentration,
interference increased with increasing glucose concentration to varying
extents (up to 200%) amongst the six analysers. At constant glucose
concentration, interference decreased with increasing creatinine
concentration in analysers using the alkaline picrate reaction but
increased in the Kodak analyser using enzymatic assay.
Conclusions. Interference of creatinine measurement in
CAPD fluid is dependent on glucose and creatinine concentrations, and each
centre should derive specific correction formulae for its analytical
system. Keywords: CAPD fluid; creatinine measurement;
glucose interference
ORIGINAL ARTICLES
Interference of creatinine measurement in CAPD fluid is dependent on glucose and creatinine concentrations
Departments of Chemical Pathology and Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong; Corresponding author
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