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Nephrology Dialysis Transplantation, Vol 12, Issue 1 137-140, Copyright © 1997 by Oxford University Press

ORIGINAL ARTICLES

Pharmacokinetics of carboplatin and etoposide in a haemodialysis patient with Merkel-cell carcinoma

S Suzuki, M Koide, S Sakamoto and T Matsuo
Department of Internal Medicine, Hyogo Prefectural Awaji Hospital, Sumoto, Hyogo 656, Japan; Corresponding author

We present a Merkel-cell carcinoma patient with chronic renal failure requiring haemodialysis and evaluate the pharmacokinetics of carboplatin and etoposide during haemodialysis. The area under the concentration-time curve of carboplatin was increased by prolonging the interval between administration and haemodialysis. However, that of etoposide was not changed. Carboplatin showed good membrane permeability in haemodialysis, while etoposide showed no permeability. In conclusion, the pharmacokinetics of carboplatin could be controlled by haemodialysis and the interval between chemotherapy and haemodialysis. However, the pharmacokinetics of etoposide were not affected. Keywords: carboplatin; etoposide; haemodialysis patient; Merkel-cell carcinoma
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