Skip Navigation

This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (31)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Ballanti, P.
Right arrow Articles by Bonucci, E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ballanti, P.
Right arrow Articles by Bonucci, E.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nephrol Dial Transplant (1996) 11: 663-667
© 1996 European Renal Association-European Dialysis and Transplant Association

research-article

Frequency of adynamic bone disease and aluminium storage in Italian uraemic patients—retrospective analysis of 1429 iliac crest biopsies

P. Ballanti, B. Martin Wedard and E. Bonucci

Department of Experimental Medicine and Pathology, Section of Pathological Anatomy, La Sapienza University Rome, Italy

Correspondence and offprint requests to: Correspondence and offprint requests to: Ermanno Bonucci MD, Department of Experimental Medicine and Pathology, Section of Pathological Anatomy, La Sapienza University, Viale Regina Elena, 324, I-00161 Rome, Italy

BACKGROUND.: Adynamic bone disease was initially attributed to aluminium intoxication in association with low circulating levels of parathyroid hormone. More recently adynamic bone disease has been described even in the absence of aluminium intoxication.

PURPOSE OF THE STUDY.: It was the purpose of this retrospective analysis of 1429 iliac crest biopsies sent to our laboratory from 1985 to 1994 by 41 Italian nephrology and dialysis centres to assess the frequency of adynamic bone disease and aluminium accumulation.

METHODS.: Adynamic bone disease was diagnosed by histological and histodynamic (tetracycline labelling) analysis, on the basis of predetermined criteria. Aluminium accumulation was assessed by aluminon histochemical staining.

RESULTS.: The frequency of adynamic bone disease was fairly constant at approximately 15% from 1985 to 1994. In contrast, aluminium accumulation, defined as positive aluminon histochemical staining, decreased during the same period from 36% to 4%.

CONCLUSIONS.: Our data clearly show a dissociation of the incidence of adynamic bone disease and aluminium accumulation in bone. At least today, given the low prevalence of aluminium intoxication, factors other than aluminium are the main cause of adynamic bone disease.

Keywords: adynamic bone disease; aluminium accumulation; bone biopsy


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Nephrol Dial TransplantHome page
S. J. Steddon, C. W. McIntyre, N. J. Schroeder, J. M. Burrin, and J. Cunningham
Impaired release of interleukin-6 from human osteoblastic cells in the uraemic milieu
Nephrol. Dial. Transplant., December 1, 2004; 19(12): 3078 - 3083.
[Abstract] [Full Text] [PDF]

Home page
 Arch SurgHome page
F.-F. Chou, J.-B. Chen, C.-H. Lee, S.-H. Chen, and S.-M. Sheen-Chen
Parathyroidectomy Can Improve Bone Mineral Density in Patients With Symptomatic Secondary Hyperparathyroidism
Arch Surg, September 1, 2001; 136(9): 1064 - 1068.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.