Nephrol Dial Transplant (1996) 11: 521-525
© 1996 European Renal Association-European Dialysis and Transplant Association
other
Iohexol clearance for GFR-determination in renal failure—single or multiple plasma sampling?
Division of Nephrology, Department of Vascular and Renal Diseases, University Hospital Malmö 1Department of Diagnostic Radiology, University Hospital Malmö 2Department of Clinical Chemistry, University Hospital Lund, Sweden
Correspondence and offprint requests to: Correspondence and offprint requests to: Gunnar Sterner MD, Division of Nephrology, Department of Vascular and Renal Diseases, Malmö University Hospital, S-205 02 Malmö, Sweden
The present study examined the agreement between single and multiple sample plasma clearance of iohexol, a non-ionic contrast agent, in renal failure. Sixty-five patients with varying degree of renal insufficiency received 10 ml iohexol (300 mg I/ml) i.v. and plasma samples were collected four times during the following 3–24 h. Plasma-iodine concentrations were determined by X-ray fluorescence. Predicted creatinine clearance was used to choose one of the samples for determination of single sample clearance. A single plasma specimen collected at 4 h for GFR above 50 ml/min, at 7 h for GFR between 20 and 50 ml/min, and at 24 h for GFR below 20 ml/min gave values in good agreement with those based on a four sample slope clearance. No sign of nephrotoxicity was noted after administration of the contrast agent. It is concluded that single sample plasma clearance after single injection of iohexol gives a good estimate of GFR in renal failure and is advantageous in clinical practice.
Keywords: glomerular filtration rate; iohexol; single sample clearance; NAG
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  G. J. Schwartz and D. F. Work Measurement and Estimation of GFR in Children and Adolescents Clin. J. Am. Soc. Nephrol., November 1, 2009; 4(11): 1832 - 1843. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. J. Bird, C. Peters, A. R. Michell, and A. M. Peters Effect of extracellular fluid volume on single-sample measurement of glomerular filtration rate Nephrol. Dial. Transplant., January 1, 2009; 24(1): 104 - 108. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Agarwal, J. E. Bills, P. M. Yigazu, T. Abraham, A. B. Gizaw, R. P. Light, D. M. Bekele, and G. G. Tegegne Assessment of Iothalamate Plasma Clearance: Duration of Study Affects Quality of GFR Clin. J. Am. Soc. Nephrol., January 1, 2009; 4(1): 77 - 85. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Tidman, P. Sjostrom, and I. Jones A Comparison of GFR estimating formulae based upon s-cystatin C and s-creatinine and a combination of the two Nephrol. Dial. Transplant., January 1, 2008; 23(1): 154 - 160. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Grubb, U. Nyman, J. Bjork, V. Lindstrom, B. Rippe, G. Sterner, and A. Christensson Simple Cystatin C-Based Prediction Equations for Glomerular Filtration Rate Compared with the Modification of Diet in Renal Disease Prediction Equation for Adults and the Schwartz and the Counahan-Barratt Prediction Equations for Children Clin. Chem., August 1, 2005; 51(8): 1420 - 1431. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. G. Bostom, F. Kronenberg, and E. Ritz Predictive Performance of Renal Function Equations for Patients with Chronic Kidney Disease and Normal Serum Creatinine Levels J. Am. Soc. Nephrol., August 1, 2002; 13(8): 2140 - 2144. [Abstract] [Full Text] [PDF]
|
|