Nephrol Dial Transplant (1995) 10: 1145-1148
© 1995 European Renal Association-European Dialysis and Transplant Association
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Association of M235T variant of the angiotensinogen gene with familial hypertension of early onset
1Department of Internal Medicine, Division of Nephrology, University of Heidelberg Berlin-Buch, Germany 2Department of Internal Medicine, Division of Nephrology, Free University of Berlin Berlin-Buch, Germany 3Max-Delbrück Center for Molecular Medicine Berlin-Buch, Germany
Correspondence and offprint requests to: Correspondence and offprint requests to: Dr Susanne Schmidt, Department of Internal Medicine, Department of Internal Medicine, University of Heidelberg, Bergheimer Str. 56a, 69115 Heidelberg, Germany
A higher frequency of a variant of the angiotensinogen gene characterized by a transition in exon 2 causing a replacement of methionine by threonine (M235T) has recently been found in hypertensive individuals, but not all authors were able to confirm this observation. We examined (i) 219 patients with primary hypertension, (ii) 92 normotensive controls (spouses), and (iii) a sample of the general population (blood donors, n=139). Analysis of genomic DNA was performed by PCR amplification and alleles were separated on agarose gels. In the general population and in normotensive spouses the respective frequencies of the T and M alleles were: general population: M=0.6, T=0.4; normotensive spouses: M=0.59, T=0.41. A significantly higher frequency of the 235T allele was found in hypertensive individuals with a family history of hypertension and an onset of hypertension before 50 years of age (spouses: 0.41 versus HT with age of onset < 50 years and family history of HT: 0.56; P=0.01 by 
2). In conclusion, the present study confirms the observation of a higher frequency of the 235T allele of the angiotensinogen gene in hypertension and identifies individuals with family history and early onset of hypertension as individuals at risk.
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