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Nephrol Dial Transplant (1995) 10: 2269-2273
© 1995 European Renal Association-European Dialysis and Transplant Association

research-article

Dry skin (xerosis) in patients undergoing maintenance haemodialysis: the role of decreased sweating of the eccrine sweat gland

T.-H. Park2, C.-H. Park1, S.-K. Ha1,, S.-H. Lee2, K.-S. Song3, H.-Y. Lee1 and D.-S. Han1

1The Institute of Kidney disease Yonsei University, Departments of Internal Medicine, Yongdong Severance Hospital, Yonsei University College of Medicine Seoul, Korea 2The Institute of Kidney disease Yonsei University, Departments of Dermatology, Yongdong Severance Hospital, Yonsei University College of Medicine Seoul, Korea 3The Institute of Kidney disease Yonsei University, Departments of Clinical Pathology, Yongdong Severance Hospital, Yonsei University College of Medicine Seoul, Korea

Correspondence and offprint requests to: Correspondence and offprint requests to: Sung-Kyu Ha, Dapartment of Internal Medicine, Yongdong Severence Hospital, Yonsei University College of Medicine, Seoul, Korea

The aetiology and the pathophysiological mechanisms underlying the development of dry skin in uraemia are still unclear, but the hydration status of stratum corneum clearly influences the appearance of skin. The xerotic skin texture is often referred to as ‘dry skin’ and has been suggested as a cause of uraemic pruritus. To understand the aetiology of dry skin in uraemia we measured the status of skin surface hydration of uraemic patients with the corneometer and skin surface hydrometer, the functional capacity and the urea concentration of stratum corneum and the response of eccrine sweat gland to sudorific agent (0.05% pilocarpine HCL) in 18 age-matched haemodialysis patients and 10 healthy volunteers. We also performed the water sorption-desorption test to uraemic and control subjects after application of urea in various concentrations. Uraemic patient's skin showed decreased water content compared to control subjects. However, we found no correlation between dry skin and pruritus. Although the urea concentration of the horny layer in uraemic patients was elevated compared to control subjects (28.2 ug/cm2 vs 5.04 ug/cm2, P<0.05), its moisturizing effect to relieve pruritus is questionable because its artificial application revealed no improvement of the functional capacity of horny layer in concentration 5 times higher than the physiological concentration. Uraemic patients showed decreased sweating response to sudorific agent. In conclusion, the functional abnormalities of eccrine sweat glands may be account for dry skin in uraemic patients at least in part, but there is no correlation between xerosis and pruritus.

Keywords: xerosis; haemodialysis; eccrine sweat gland


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Home page
 Nephrol Dial TransplantHome page
J. C. Szepietowski, A. Reich, and R. A. Schwartz
Uraemic xerosis
Nephrol. Dial. Transplant., November 1, 2004; 19(11): 2709 - 2712.
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