Nephrol Dial Transplant (1995) 10: 2043-2048
© 1995 European Renal Association-European Dialysis and Transplant Association
research-article
Blood-pressure-independent wall thickening of intramyocardial arterioles in experimental uraemia: evidence for a permissive action of PTH
Departments Pathology and Nephrology, Ruperto Carola University Heidelberg Germany
Correspondence and offprint requests to: Correspondence and offprint requests to: Dr med. Kerstin Amann, Department Pathology, Im Neuenheimer Feld 220, D-69120 Heidelberg, Germany
BACKGROUND.: Abnormalities in cardiovascular structures, e.g. LV hypertrophy and thickening of vessels (arteries, arterioles, veins) are hallmarks of renal failure. They are in part independent of elevated blood pressure. Parathyroid hormone (PTH) has been shown to affect cardiac function and has also been identified as a permissive factor in the genesis of cardiac fibrosis.
PURPOSE OF THE STUDY.: The present study in rats with experimental renal failure was designed to examine whether PTH was permissive for wall thickening of intramyocardial arterioles as well.
METHODS.: Male SD rats were sham operated or sub-totally nephrectomized and maintained for 2 weeks. Subgroups of subtotally nephrectomized (SNX) rats were parathyroidectomized (PTX). Saline or rat 1, 34 PTH was administered by osmotic minipump. Eucalcaemia was maintained in PTX animals by a high-calcium diet (3%). Serum calcium was not statistically different between the groups. After perfusion fixation, intramyocardial arterioles were assessed using stereological techniques (wall thickness; wall/lumen ratio; minimal lumen diameter; length density).
RESULTS.: In random samples of the left ventricle, wall thickness of arterioles was 2.2±0.25 µm in sham-op controls and 2.76±0.41 in SNX (n=at least 8 animals per group). SNX-PTX animals+solvent did not differ significantly from sham-op controls (2.08±0.42 µm), while SNX-PTX animals+PTH had values not significantly different from SNX (2.59±0.54 µm). Differences in wall thickness were not paralleled by differences in systolic blood pressure (sham-op 110±13.3 mmHg; SNX 138±8.4 mmHg, SNX PTX+solvent 142±5.2 mmHg; SNX-PTX+PTH 148±5.7 mmHg). PTH treated animals showed signs of marked vascular smooth-muscle cell and endothelial-cell activation.
CONCLUSIONS.: The data suggest that wall thickening of intramyocardial arterioles in short-term experimental uraemia is dependent upon the presence of PTH (permissive effect).
Keywords: PTH; uraemia; vascular hypertrophy; cardiac microvasculature; cardiac hypertrophy
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